RESIHANCE 40MG DESCRIPTION Resihance 40mg consist of protein kinase inhibitor with a similar structure to sorafenib. It is hoping to act by prohibiting multiple signalling pathways contains in angiogenesis and tumour growth. Resihance 40mg Tablet is commonly given after other chemotherapy have been tried without success. Resihance 40mg which is used as prescription drugs under the supervision of medical practioners. INDICATION: Resihance 40mg is an anticancer drug which is; • Indicated for the treatment of Hepatocellular carcinoma • Indicated for the treatment of Colorectal cancer • Indicated for the treatment of Gastrointestinal stromal tumor. ADME Time to peak plasma is 4 hours and concentration is 2.5mcg/mL for single dose; Bioavailability is 69-83% Regorafenib has protein bounding about 99.5% and M-2 active metabolite is 99.8%; M-5 active metabolite is 99.95% The drug Regorafenib is metabolized by CYP3A4 and UGT1A9 Eliminated via feces 71%; 19% ...